In this report we introduce the notion of holistic arguments. A holistic argument is formed by two arguments, an argument a and an argument h(a) which says something about a. This means that h(a) is a meta-argument of a. In order to manage the relations between holistic arguments, an extension of Dung’s argumentation frameworks is presented. This extension will be called holistic argumentation frameworks. We present an application of holistic argumentation frameworks in a medical scenario. In particular, we define an argumentation approach for modeling medical diagnosis. For capturing the knowledge of the medical scenario, normal and abductive logic programs are used.